某聚氯乙烯分厂的氯乙烯职业健康风险评价Occupational health risk assessment on vinyl chloride: a case study via a PVC factory
宋从波;李静;黄德寅;刘茂;
摘要(Abstract):
以某化工企业的聚氯乙烯分厂为研究对象,引入美国环境保护署(EPA)推荐的健康风险评价四步法,即危害鉴定、剂量-反应评价、暴露评价和风险表征,对不同作业任务(清釜、看釜、巡检和配料)工人的氯乙烯职业暴露进行健康风险评价。结果表明,从非致癌效应来看,看釜、巡检和配料岗位工人暴露于VC引起肝细胞多态性的HI值均高于安全阈值1,其中看釜工的危害指数最大,引起的不利健康效应最严重。从致癌效应来看,清釜工暴露于VC引起肝血管肉瘤的风险处于可接受水平;而看釜工患肝血管肉瘤的风险值R,达到可接受上限10-4对应的工作年限ED=1.91 a,因此,需要尽可能地采用安全防护措施减少该岗位的职业暴露。巡检和配料岗位的肝血管肉瘤风险达到可接受水平上限10-4时,对应的工作年限分别为4.36 a和9.33 a。由于健康风险评价更侧重长期暴露危害物质对人体健康的影响,即使工作场所满足国标规定的浓度阈值,仍然存在工人长期暴露于低浓度致癌物的风险。
关键词(KeyWords): 职业卫生工程;氯乙烯;健康风险评价;危害指数;致癌风险
基金项目(Foundation): 国家科技支撑计划项目(2012BAJ24B04);; 天津市科技支撑计划项目(13ZCZDSY02300)
作者(Authors): 宋从波;李静;黄德寅;刘茂;
参考文献(References):
- [1]DOLL R.Effects of exposure to vinyl chloride:an assessment of the evidence[J].Scandinavian Journal of Work,Environment&Health,1988,14(2):61-78.
- [2]MIAO Wenbin(缪文彬),WANG Wei(王威),XIA Zhaolin(夏昭林).A review of carcinogenic mechanism of vinyl chloride[J].China Occupation Medicine(中国职业医学),2007,34(5):420-422.
- [3]HUANG Meiyuan(黄美媛).A review of carcinogenic effcets of vinyl chloride[J].China Cancer(中国肿瘤),1995,4(4):32-35.
- [4]International Agency for Research on Cancer.Monographs on evaluation of carcinogenic risk to humans,Volume 97[R].Lyon:IARC Monographs Working Group,2008:311-425.
- [5]GBZ 2.1—2007 Occupational exposure limit of harmful factors at workplace(part 1):chemical hazards(工作场所有害因素职业接触限值第1部分:化学有害因素)[S].
- [6]WANG Jingqin(王敬钦).A investigation of chronic occupational hazard of vinyl chloride[J].Chinese Journal of Industrial Hygiene and Occupational Diseases(中华劳动卫生职业病杂志),1995,6(13):343-344.
- [7]FOX A J,COLLIER P F.Mortality experience of workers’exposure to vinyl chloride monomer in the manufacture of polyvinyl chloride in Great Britain[J].British Journal of Industrial Medicine,1977,34:1-10.
- [8]BYREN D,ENGHOLM G,ENGLUND A,et al.Mortality and cancer morbidity in a group of Swedish VCM and PVC workers[J].Environmental Health Perspect,1976,17:167-170.
- [9]WEBER H,REINL W,GREISER E.German investigations on morbidity and mortality of workers exposed to vinyl chloride[J].Environmental Health Perspect,1981,41:95-99.
- [10]GU Zuwei(顾祖维),CHEN Ziqiang(陈自强),WANG Yilan(王鋎兰).Progress on the occupational people and residents health hazard assessment of vinyl chloride[J].Occupational Medicine(职业医学),1990,17(3):173-174.
- [11]LI Yufang(李玉芳),SHAO Tao(邵涛),REN Xuefeng(任雪峰),et al.Exposure estimation of VCM and its occupational health hazard[J].Occupational Health and Emergency Rescue(职业卫生与应急救援),2002,20(2):69-71.
- [12]ZHANG Jun(张军).Analysis of occupational check-up result for vinyl chloride production enterprise[J].Industrial Health and Occupational Diseases(工业卫生与职业病),2005,31(3):167-168.
- [13]LI Jing(李静),LIU Xufeng(刘旭峰),LIU Mao(刘茂).Review of occupational health risk research on toxic chemicals[C]//Proc of the 20th Academical Annual Conference of Occupational Health and Safety Association(第二十届海峡两岸及香港、澳门地区职业安全健康学术研讨会暨中国职业安全健康协会2012学术年会论文集),Chengdu,2012.Beijing:China Occupational Safety and Health Association,2012.
- [14]National Academy of Sciences.Risk assessment in the federal government:managing the process[M].Washington:National Academy Press,1983.
- [15]U.S.EPA.A review of the reference dose and reference concentration processes,EPA/630/P-02/002F[R].Washington:U.S.Environmental Protection Agency,Risk Assessment Forum,2002.